COMPOUNDS FOR INHIBITING P25 AND PROCESS FOR PREPARING SAME

摘要

A novel P25 inhibiting compound is provided to increase the activity of beta-secretase in a P25 over-expressed cell line, thereby being usefully used for preventing or treating degenerative brain diseases such as Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease, huntington's disease, Niemann-Pick disease and cerebral hemorrhage. A compound for inhibiting P25 is represented by the formula(1) and is prepared by reacting a compound represented by the formula(6) with a compound represented by the formula(7) to obtain a compound represented by the formula(1a) and then reacting the compound of the formula(1a) with R3-Z and/or R4-Z. In the formulae, R1 is H or C1-4 alkyl; R2 is H, C1-4 alkyl, C1-4 alkoxy or halogen; each R3 and R4 is independently H, C1-6 alkyl, C1-6 cycloalkyl, C1-6 alkoxy carbonyl, or allyl; X is O or S; and Z is halogen. A pharmaceutical composition for preventing or treating degenerative brain diseases comprises the compound of the formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient.