| 摘要 |
<p>The purpose of this invention is therefore to search receptors based on the information about HN signaling pathway in order to finally find Humanin receptor or Humanin-like polypeptide receptor (HNR), and to reveal a mechanism of promoting or suppressing the intracellular signal transduction for showing neuroprotecting activity of HN and identify a compound involved in the mechanism, to establish a method for screening of HNR agonist and HNR antagonist, to utilize the screened compound in development of a drug for the treatment of neurodegenerative disease, especially AD, to provide an assay system of AD neuronal cell death, and to provide methods for the compulsory expression of HNR gene or knocking-out of intracellular genes. The present invention relates to a Humanin receptor or Humanin-like polypeptide receptor (HNR) comprising at least two kinds of proteins selected from the group consisting of gp130 or its partial polypeptide, CNTRF receptor alpha chain (CNTF-R) and WSX-1.</p> |
