actinobacillus pleuropneumoniae virulence genes

摘要

The application provides an attenuated Actinobacillus pleuropneumoniae bacterium having a mutation in a gene required for bacterial virulence, wherein said gene comprises the nucleotide sequence SEQ ID NO: 10. The application also provides an attenuated Actinobacillus pleuropneumoniae bacterium having a mutation in a nucleic acid sequence responsible for, or involved in, controlling expression of a gene required for bacterial virulence, wherein said nucleic acid sequence comprises the nucleotide sequence SEQ ID NO: 47.