Stimulation of the synthesis and of the activity of an isoform of lysyl oxidase-like LOXL for stimulating the formation of elastic fibres

摘要

A method for screening for a substance which promotes the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform comprising placing a test substance in contact with skin cells expressing LOXL, analysing the activity of LOXL and selecting substances that stimulate LOXL expression. Also claimed is a method for screening for a substance that promotes the formation of LOXL comprising placing a test substance in contact with cells capable of expressing LOXL and which have a decreased LOXL expression with respect to the level of LOXL expression in cells originating from infant foreskin and analysing the expression of LOXL.