发明名称 |
VERFAHREN ZUM NACHWEIS IN HEFE FÜR MITTELS DIE PROTEINFALTUNG BEEINFLUSSEN |
摘要 |
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes. |
申请公布号 |
AT382704(T) |
申请公布日期 |
2008.01.15 |
申请号 |
AT20020718994T |
申请日期 |
2002.02.15 |
申请人 |
UNIVERSITY OF CHICAGO |
发明人 |
LINDQUIST, SUSAN;KROBITSCH, SYLVIA;OUTEIRO, TIAGO |
分类号 |
C12Q1/02;G01N33/50;A61K45/00;A61P25/14;A61P25/16;C12N15/09;G01N33/15;G01N33/68 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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