发明名称 |
CHOLENIC ACID AMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF |
摘要 |
Novel sterol derivatives of formula (I), in which: R1 represents a hydroxyl group or protected hydroxyl group, R2 represents a hydrogen atom and a double bond is present at c, or R1 and R2 together represent an oxo group and a double bond is present at b or double bonds are present at a and b; R3 represents a methyl group having .alpha.- or .beta.-configuration; R4 and R5, which may be the same or different, are selected from hydrogen atoms and aliphatic, cycloaliphatic, araliphatic and aryl groups, or togheter with the nitrogen atom to which they are attached form a heterocyclic group; and X represents a polymethylene group containing 2-5 carbon atoms, an oxa group-containing analogue thereof in which a methylene group other than that attached to the -CO.NR4R5 moiety is replaced by an oxygen atom, or an unsaturated analogue thereof containing up to two double bonds. Active compounds of the invention exhibit potent effects on the modulation of cell growth and differentiation and possess an advantageous therapeutic ratio by virtue of their low levels of calcaemic activity.
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申请公布号 |
CA2319763(C) |
申请公布日期 |
2008.01.15 |
申请号 |
CA19992319763 |
申请日期 |
1999.03.08 |
申请人 |
RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY, INC. |
发明人 |
RAMGOPAL, MALATHI;SETTY, SUNDARA KATUGAM SRINIVASASETTY;HESSE, ROBERT HENRY |
分类号 |
A61K31/575;C07J41/00;A61P1/04;A61P3/14;A61P5/18;A61P9/12;A61P11/06;A61P17/00;A61P19/02;A61P19/08;A61P21/00;A61P25/28;A61P29/00;A61P31/00;A61P35/00;A61P37/06;C07J43/00 |
主分类号 |
A61K31/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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