METHODS FOR DIAGNOSING AND TREATING HEART DISEASE

摘要

The invention provides methods of diagnosing, preventing, and treating heart disease, and screening methods for identifying compounds that can be used to treat or prevent heart disease. The diagnostic methods of the invention involve detection of mutations in genes encoding san or vtn proteins (and/or altered san or vtn levels), while the compound identification methods involve screening for compounds that affect the phenotype of organisms having mutations in genes encoding san or vtn or other appropriate models. The invention also provides for compounds identified in this manner, as well as san or vtn genes, siRNA molecules, proteins, and antibodies.