发明名称 |
HUMAN TROPHOBLAST STEM CELLS AND USE THEREOF |
摘要 |
Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, fgfr-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. These facts suggest that differentiation of the hTS cells play an important role in implantation and placentation. hTS cells could be apply to human cell differentiation and for gene and cell-based therapies. |
申请公布号 |
WO2006091766(A3) |
申请公布日期 |
2008.01.10 |
申请号 |
WO2006US06512 |
申请日期 |
2006.02.24 |
申请人 |
LEE, JAU-NAN;LEE, TONY TUNG-YING;LEE, YUTA |
发明人 |
LEE, JAU-NAN;LEE, TONY TUNG-YING;LEE, YUTA |
分类号 |
A01N43/04;A01N63/00;A01N65/00;A61K31/70;C12N5/00;C12N5/02;C12N5/071;C12N5/073;C12N5/0735;C12N15/00 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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