| 摘要 |
The invention provides a method of identifying the existence of, or susceptibility to, neurodegenerative disorder in a subject. The method comprising: (i) obtaining a sample from a subject; and (ii) detecting, in the sample, the presence of a genetic polymorphism in intron 2 of alpha-1-antichymotrypsin (ACT) gene, wherein the polymorphism is associated with neurodegenerative disorder. The invention also provides a kit for carrying out the method, methods of treatment, and medical uses of nucleic acids harbouring polymorphisms in the ACT gene and of peptides encoded thereby. |
