摘要 |
The present invention is directed to a substituted 4H-chromene represented by the Formula 1R, substantially free from the corresponding (S)-stereoisomer: The present invention also relates to the discovery that compound 1R, substantially free from the corresponding (S)-stereoisomer, is an activator of caspases and inducer of apoptosis, as well as an antivascular agent. Therefore, compound 1R, substantially free from the corresponding (S)-stereoisomer, can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth, and spread of abnormal cells occurs. Compound 1R, substantially free from the corresponding (S)-stereoisomer, also can be used for the treatment of diseases due to overgrowth of vasculature, such as solid tumors and ocular neovascularization. |
申请人 |
CYTOVIA, INC.;CAI, SUI, XIONG;DREWE, JOHN, A.;KASIBHATLA, SHAILAJA;KEMNITZER, WILLIAM, E.;TSENG, BEN, Y.;BLAIS, CHARLES;GOURDEAU, HENRIETTE;LABRECQUE, DENIS |
发明人 |
CAI, SUI, XIONG;DREWE, JOHN, A.;KASIBHATLA, SHAILAJA;KEMNITZER, WILLIAM, E.;TSENG, BEN, Y.;BLAIS, CHARLES;GOURDEAU, HENRIETTE;LABRECQUE, DENIS |