摘要 |
Disclosed herein are an HIF-I inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient The BDDF-I inhibitor shows anticancer activity thanks to the inhibition activity against HIF-I, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer, stomach cancer and breast cancer. Also, the compound having inhibition activity against HDDF-I is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HEF-l-mediated VEGF expression. |
申请人 |
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;LEE, JUNG JOON;LEE, JEONG-HYUNG;LEE, KYEONG;HONG, YOUNG-SOO;SHANTHAVEERAPPA, B.K.;JIN, YINLAN;KIM, JIN HWAN;JIN, XUEJUN |
发明人 |
LEE, JUNG JOON;LEE, JEONG-HYUNG;LEE, KYEONG;HONG, YOUNG-SOO;SHANTHAVEERAPPA, B.K.;JIN, YINLAN;KIM, JIN HWAN;JIN, XUEJUN |