Novel nucleic acid sequences encoding glutamate gated chloride channel, and recombinant expressions and host cells comprising the same are disclosed. Isolated the glutamate gated chloride channel, host cells expressing the glutamate gated chloride channel, methods of producing the glutamate gated chloride channel and antibodies specific for the glutamate gated chloride channel are also disclosed. Methods of identifying activators, inhibitors or of the glutamate gated chloride channel are disclosed.
