SMALL STREPTOCOCCUS PYOGENES ANTIGENS AND THEIR USE

摘要

The present invention relates to a peptide consisting of one antigen of S treptococcus pyogenes (S. pyogenes) of any of the SEQ ID NOS: 1 to 7 or a fu nctional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a metho d for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture o f a medicament for the immunization or treatment of a subject; the use of sa id antibody or functional fragment thereof for the manufacture of a medicame nt for the treatment of an infection; a method of diagnosing a S. pyogenes i nfection; a method for identifying a ligand capable of binding to said pepti de; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.