Disclosed are: an antibody directed against Panton-Valentine leukocidin (PVL) toxin derived from Staphylococcus aureus; a method and a kit for the detection of the toxin using the antibody; and a pharmaceutical composition for the treatment of PVL-carrying Staphylococcus aureus, which comprises an antibody directed against Panton-Valentine leukocidin toxin. Specifically, disclosed are: an antibody capable of binding to Panton-Valentine leukocidin F and having no cross-reactivity with LukD and/or HlgB; and an antibody capable of binding to Panton-Valentine leukocidin S and having no cross-reactivity with at least one member selected from LukE, HlgC and HlgA.
申请公布号
WO2008004536(A1)
申请公布日期
2008.01.10
申请号
WO2007JP63278
申请日期
2007.07.03
申请人
JUNTENDO UNIVERSITY SCHOOL OF MEDICINE;DENKA SEIKEN CO., LTD.;OHISHI, KANENARI;BABA, TADASHI;HIRAMATSU, KEIICHI;NAKATOMI, YASUO