| 摘要 |
The invention provides a compound of formula (I) : X- PYY* (3-36) (I) wherein X is selected from H, PYY<SUB>1-2</SUB> (ie Tyr Pro) and D-AlIo-Ue; PYY*(3-36) representing PYY (3-36) in which one or more residues is replaced by an acylated lysine group, the acyl group being selected from: CO-C<SUB>1-20</SUB> alkyl, CO-C<SUB>2-2O</SUB> alkenyl, CO-C<SUB>5-10</SUB> aryl and CO-C<SUB>5-10</SUB> ar-C<SUB>1-20</SUB> alkyl; a variant or derivative thereof; or a salt or solvate thereof. The compounds are effective in inducing satiety and suppressing appetite and they are thus useful in treating various diseases, including obesity. |
