METHOD OF TREATING GENETIC DISEASE CAUSED BY NONSENSE MUTATION

摘要

It is intended to provide a compound having a readthrough activity to be used as a method of treating a genetic disease caused by a nonsense mutation, a pharmaceutical composition containing the compound, and a method of treating a genetic disease caused by a nonsense mutation including administering the compound. According to the invention, the method which is a method in which a wild-type normal protein is produced in the body of a mammal from a gene in which a premature stop codon is generated by a mutation and includes administering a compound represented by the following formula (VI): (VI) (wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP> and X<SUP>1</SUP> are as defined in the description) or the like to the mammal is provided.