摘要 |
The present invention is directed to a substituted 4H-chromene represente d by the Formula (1R), substantially free from the corresponding (S)-stereoi somer: The present invention also relates to the discovery that compound 1R, substantially free from the corresponding (S)-stereoisomer, is an activator of caspases and inducer of apoptosis, as well as an antivascular agent. The refore, compound 1R, substantially free from the corresponding (S)-stereoiso mer, can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth, and spread of abnormal cells occurs. Compound 1R , substantially free from the corresponding (S)-stereoisomer, also can be us ed for the treatment of diseases due to overgrowth of vasculature, such as s olid tumors and ocular neovascularization.
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申请人 |
CYTOVIA, INC. |
发明人 |
KASIBHATLA, SHAILAJA;KEMNITZER, WILLIAM E.;TSENG, BEN Y.;DREWE, JOHN A.;CAI, SUI XIONG;BLAIS, CHARLES;LABRECQUE, DENIS;GOURDEAU, HENRIETTE |