发明名称 |
C-MET RECEPTOR REGULATION BY ANGIOTENSIN IV (AT4) RECEPTOR LIGANDS |
摘要 |
The cell surface c-Met receptor, through which hepatocyte growth factor (HGF) signals are mediated, has now been identified as the Angiotensin-IV receptor (AT(4)R) in processes that include HGF-regulated cell motility, angiogenesis cancer metastasis and others. Disclosed are angiotensin-like factor compositions and methods for using them to diagnose, prevent and/or treat conditions associated with c-Met dysregulation, including altering hepatocyte growth factor activity or c-Met receptor activity by administering an angiotensin-like factor that specifically binds to a cell surface c-Met receptor.
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申请公布号 |
US2008008701(A1) |
申请公布日期 |
2008.01.10 |
申请号 |
US20070774517 |
申请日期 |
2007.07.06 |
申请人 |
WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
HARDING JOSEPH W.;WRIGHT JOHN W.;ELIAS PATRICK D.;YAMAMOTO BRENT J. |
分类号 |
A61K39/395;A61K38/06;A61K38/07;A61K38/08;A61K38/10;A61K38/17;A61P9/00;C07K16/28;C12N5/06;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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