The invention is related to an acylated, single-chain insulin comprising the B- and the A-chain of human insulin or an analogue thereof connected by a connecting peptide, wherein a lysine residue being substituted for the natural amino acid residue in one of the positions A12-A23 in the human insulin A-chain has been chemically modified by acylation.
申请公布号
WO2007104738(A3)
申请公布日期
2008.01.10
申请号
WO2007EP52294
申请日期
2007.03.12
申请人
NOVO NORDISK A/S;MADSEN, PETER;KJELDSEN, THOMAS, BOERGLUM;TAGMOSE, TINA, MOELLER
