| 摘要 |
<p>Disclosed is a 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylate represented by the formula (I) or a salt thereof wherein R<SUP>1</SUP> represents a C<SUB>1-6</SUB> alkyl group or the like; and R<SUP>2</SUP> represents a hydrogen atom or COOR<SUP>3</SUP>, wherein R<SUP>3</SUP> represents a tert-C<SUB>4-6</SUB> alkyl group, a 2,2,2-trichloroethyl group, or a benzyl group in which the benzene ring moiety may be substituted by one or two atoms or groups independently selected from the group consisting of a halogen atom, a C<SUB>1-4</SUB> alkyl group, a C<SUB>1-4</SUB> alkoxy group, a cyano group and a nitro group. This compound is a novel intermediate for producing a tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivative (e.g., ranirestat) (which is a promising therapeutic agent for complications of diabetes) in a short process and in an economically advantageous and safe manner. Also disclosed is a process for the production of the 3-hydrazino-2,5-dioxopyrrolidine-3-carboxylate.</p> |
