ASSAYS FOR TAK1 ACTIVITY

摘要

This invention discloses methods to identify modulators of TAK1 activity comprising measuring TAK1 activity or measuring TAK1- dependent Snf1/AMPK activity. Further disclosed are methods to measure TAK1 activity comprising measuring phosphorylation of an AMPK substrate or an increase in AMPK activity resulting from an increase in TAK1 activity. Methods to treat obesity, diabetes and diseases characterized by inflammation by administering compounds that modulate TAK1 are described also.