BINDING POLYPEPTIDES WITH RESTRICTED DIVERSITY SEQUENCES
摘要
The invention provides variant CDRs comprising highly restricted amino acid sequence diversity. These polypeptides provide a flexible and simple source of sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
申请公布号
WO2007064919(A3)
申请公布日期
2008.01.10
申请号
WO2006US46045
申请日期
2006.12.01
申请人
GENENTECH, INC.;BIRTALAN, SARA C.;FELLOUSE, FREDERIC A.;SIDHU, SACHDEV S.
发明人
BIRTALAN, SARA C.;FELLOUSE, FREDERIC A.;SIDHU, SACHDEV S.