METHODS FOR TREATMENT AND PREVENTION OF OTITIS MEDIA USING NONIONIC SURFACTANTS TO FACILITATE TRANSMEMBRANE DRUG DELIVERY INTO THE MIDDLE EAR

摘要

Methods for treating and preventing middle ear infections by transmembrane administration of medicament-containing transmembrane carrier compositions comprising a nonionic polymer surfactant, such as an alkyl aryl polyether alcohol (e.g., tyloxapol) to the tympanic membrane. The medicaments delivered according to the methods of the invention include antibiotic, antiviral, anti-fungal and anti-inflammatory agents that are useful in treatment and/or prophylaxis of middle ear infections and their sequelae.