ГЛИКОПЭГИЛИРОВАННЫЙ ГРАНУЛОЦИТАРНЫЙ КОЛОНИЕСТИМУЛИРУЮЩИЙ ФАКТОР

摘要

FIELD: chemistry. ^ SUBSTANCE: invention relates to granulocyte colony-stimulating factor peptide conjugates formed by linkage through an intact glycosyl linker group of (polyethylene glycol) PEG fragments. Said conjugates are obtained from glycosylated and non-glycosylated peptides under the effect of glycosyl transferase. Glycosyl transferase links a fragment of modified sugar to an amino acid or glycosyl peptide residue. ^ EFFECT: improved method. ^ 35 cl, 24 dwg, 2 tbl, 6 ex