| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for preparation of 1,5-dideoxy-1,5-imino hexitols of hexose sugars from new hydroxy group-protected oxime intermediates. SOLUTION: The method includes the processes of (a) reacting an acid ester or a hydrazide of a 5-hexulosonic acid oxime or alkylimine with hydrogen and a hydrogenation catalyst in an acidic solvent to form a 5-imino-5-deoxyaldonic acid lactam and (b) reducing the lactam with a reducing agent to form the 1,5-dideoxy-1,5-imino hexitol. The hexitols are useful as drugs. COPYRIGHT: (C)2008,JPO&INPIT
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