<p>The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is engineered to facilitate mutation of a nucleic acid target corresponding to that entity and select for desirable mutants. As applied to populations of host cells, the invention provides a means to generate and contemporaneously select mutants of interest, allowing for the production of extremely diverse libraries enriched in the most "fit" mutants.</p>
申请公布号
WO2008005529(A2)
申请公布日期
2008.01.10
申请号
WO2007US15568
申请日期
2007.07.05
申请人
THE TRUSTEES COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;CORNISH, VIRGINIA, W.;PERALTA-YAHYA, PAMELA;BRONSON, JONATHAN
发明人
CORNISH, VIRGINIA, W.;PERALTA-YAHYA, PAMELA;BRONSON, JONATHAN