摘要 |
The cell surface c-Met receptor, through which hepatocyte growth factor (HGF) signals are mediated, has now been identified as the Angiotensin-IV receptor (AT(4)R) in processes that include HGF-regulated cell motility, angiogenesis cancer metastasis and others. Disclosed are angiotensin-like factor compositions and methods for using them to diagnose, prevent and/or treat conditions associated with c-Met dysregulation, including altering hepatocyte growth factor activity or c-Met receptor activity by administering an angiotensin-like factor that specifically binds to a cell surface c-Met receptor. |
申请人 |
WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION;HARDING, JOSEPH, W.;WRIGHT, JOHN, W.;ELIAS, PATRICK, D.;YAMAMOTO, BRENT, J. |
发明人 |
HARDING, JOSEPH, W.;WRIGHT, JOHN, W.;ELIAS, PATRICK, D.;YAMAMOTO, BRENT, J. |