发明名称 |
POROUS POLYMERIC ARTICLES |
摘要 |
Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three- dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores. In some embodiments, the porous structure is constructed and arranged for use as a template for ultrafiltration, cell growth, and/or for forming complex, biomimetic, porous biohybrid organs, where living cells can be immobilized and perform their normal physiological functions. |
申请公布号 |
WO2008005035(A1) |
申请公布日期 |
2008.01.10 |
申请号 |
WO2006US35610 |
申请日期 |
2006.09.12 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;YING, JACKIE, Y.;CHOW, EDWIN PEI YONG;LOH, JEREMY MING HOK;SCHUMACHER, KARL |
发明人 |
YING, JACKIE, Y.;CHOW, EDWIN PEI YONG;LOH, JEREMY MING HOK;SCHUMACHER, KARL |
分类号 |
C08J9/00;A61P27/00 |
主分类号 |
C08J9/00 |
代理机构 |
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