TISSUE ADHESIVES WITH MODIFIED ELASTICITY

摘要

An embodiment of the invention is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether amine with a bifunctional crosslinker of the formula: X¹-R-X². Another embodiment is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether having at least three arms and three electrophilic endgroups with a primary diamine crosslinker of the formula: NH₂-R²-NH₂, followed by treating of the chain-extended product so as to convert the remaining electrophilic endgroups to amine endgroups. Crosslinking of the chain-extended polyamine products with an oxidized polysaccharide provides useful tissue adhesives with modified elasticity, that provides greater compliance to underlying tissue, and improved stability in aqueous environments.