TREATMENT OF HYPERCHOLESTEROLEMIA, HYPERTRIGLYCERIDEMIA AND CARDIOVASCULAR-RELATED CONDITIONS USING PHOSPHALIPASE-A2 INHIBITORS

摘要

The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.