| 发明名称 |
MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS |
| 摘要 |
<p>Method of producing a temperature sensitive (ts) influenza virus, the method comprising:(a) introducing at least one mutation resulting in an amino acid substitution at a position selected from the group consisting of: PA431 ; PB2630; PA497 ; NP55 ; NP114 ;NP 410; NP 5 °9 ; M1159 and M1183 into an influenza B virus genome; and (b) replicating the mutated influenza virus genome under conditions whereby virus is produced.</p> |
| 申请公布号 |
EP1499348(A4) |
申请公布日期 |
2008.01.09 |
| 申请号 |
EP20030724208 |
申请日期 |
2003.04.25 |
| 申请人 |
MEDIMMUNE VACCINES, INC. |
发明人 |
HOFFMAN, ERICH;JIN, HONG;LU, BIN;DUKE, GREG;KEMBLE, GEORGE, WILLIAM |
| 分类号 |
C12N15/09;A61K39/145;A61P31/16;C07K14/11;C12N5/02;C12N7/00;C12N7/02;C12N7/04;C12N15/85;C12N15/87;(IPC1-7):A61K39/21 |
主分类号 |
C12N15/09 |
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