发明名称 |
AZOLE DERIVATIVES IN THE FORM OF LIPASE AND PHOSPHOLIPASE INHIBITORS |
摘要 |
<p>The invention relates to azole derivatives of the general formula I as defined in the present application as well as to their uses in treatment of conditions that would benefit from their inhibitory effect on hormone sensitive lipase, HSL, an allosteric enzyme in adipocytes which is inhibited by insulin and is responsible for the breakdown of fats in fat cells and thus for transferring fat constituents into the blood stream. Inhibition of this enzyme is therefore equivalent to an insulin-like effect of the compounds of the invention.</p> |
申请公布号 |
EP1874741(A1) |
申请公布日期 |
2008.01.09 |
申请号 |
EP20060761897 |
申请日期 |
2006.04.13 |
申请人 |
SANOFI-AVENTIS |
发明人 |
MUELLER, GUENTER;PETRY, STEFAN;ZOLLER, GERHARD;TENNAGELS, NORBERT;HEUER, HUBERT |
分类号 |
C07D261/20;A61K31/423;A61K31/428;A61K31/437;A61K31/454;A61P3/10;C07D275/04;C07D413/12;C07D498/04;C07D513/04 |
主分类号 |
C07D261/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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