发明名称 |
Oral formulations for the selective inhibition of thrombin comprising boronic acid species |
摘要 |
<p>A pharmaceutical formulation adapted for oral administration, whether directly or after combining with a liquid, and comprising
a) a first species selected from (a) boronic acids of formula (I), (b) boronate anions thereof, and (c) any equilibrium form of the aforegoing (e.g. an anhydride); and
(b) a second species selected from the group consisting of pharmaceutically acceptable metal ions.</p><p>Formula (I) comprises specified peptidyl boronic acids having anti-thrombotic activity and the formulations are useful for the treatment of thrombosis. An exemplary boronic acid is Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)<Sub>2</Sub>.</p> |
申请公布号 |
EP1695712(A3) |
申请公布日期 |
2008.01.09 |
申请号 |
EP20060113648 |
申请日期 |
2003.09.09 |
申请人 |
TRIGEN LIMITED |
发明人 |
MADGE, DAVID, JONATHAN;DOLMAN, MARK;COMBE-MARZELLE, SOPHIE, MARIE;DEADMAN, JOHN, JOSEPH;KENNEDY, ANTHONY, JAMES;KAKKAR, SANJAY, KUMAR |
分类号 |
C07F5/02;A61K31/69;A61K38/00;A61K45/06;C07K5/06;C07K5/065 |
主分类号 |
C07F5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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