Altered OspA of Borrelia burgdorferi

摘要

Provided herein are OspA polypeptides from Lyme Disease-causing <Italic>Borrelia</Italic> having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.