TYROSINE KINASE INHIBITOR COMPOSITIONS AND METHODS FOR MANUFACTURING AND USING THEM IN THE TREATMENT OF DISEASE

摘要

A new ErbB-based ligand binding molecule is disclosed along with its method of preparation and use. The binding molecule is a protein expressed from a recombinant DNA molecule. The protein contains an ErbB extracellular domain that binds to activating ligands. These binding elements act as traps to bind and sequester circulating ligands, thus making them unavailable for binding to cellular ErbB receptors.