发明名称 |
Process for the optical resolution and recycling of tomoxetine |
摘要 |
The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention further provides the conversion of the enantiomer obtained from the optical resolution into atomoxetine or a pharmaceutically acceptable salt thereof.
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申请公布号 |
US7317127(B2) |
申请公布日期 |
2008.01.08 |
申请号 |
US20050170379 |
申请日期 |
2005.06.28 |
申请人 |
TEVA PHARMACEUTICAL FINE CHEMICALS S.R.L |
发明人 |
CASTELLI EUGENIO;LO MONACO GIUSEPPE;MANTOVANI SILVIA;DAVERIO PAOLA;RIVA PAOLO;VAILATI ALESSANDRA;BIANCHI STEFANO |
分类号 |
C07C209/88;A61K31/135;C07B57/00 |
主分类号 |
C07C209/88 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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