PROPOFOL-CONTAINING FAT EMULSION

摘要

A propofol-containing fat emulsion comprising 0.1 to 2 w/v% of propofol, 10 to 20 w/v% of an oily component and 2 to 5 w/v% of an emulsifying agent, the oily component being contained in an amount about 5 to 200 times the weight of the propofol, the emulsifying agent being contained in an amount about 0.9 to 50 times the weight of propofol, the average particle diameter of the resulting emulsion particles being 180 nm or smaller; and a process for producing the propofol-containing fat emulsion. The propofol-containing fat emulsion can reduce the angialgia during administration without the need of addition of a local anesthetics such as lidocaine.