| 摘要 |
A naphthalene compound, a method for preparing the compound, and a pharmaceutical composition containing the compound are provided to treat the disorder of melatonin system. A naphthalene compound is represented by the formula I, wherein R1 is R4 or NHR4; R2 is a linear or branched C1-C6 alkyl group substituted with a linear or branched C1-C6 alkoxy group, OH, OSO2Me, N3, NRR', NHCOR'' or NHSO2R''; R3 is H, halogen atom, a linear or branched C1-C6 alkyl group or a linear or branched C1-C6 alkenyl group; R4 is a linear or branched C1-C6 alkyl group, a linear or branched C1-C6 alkenyl group, a linear or branched C1-C6 haloalkyl group, a linear or branched C1-C6 polyhaloalkyl group, a C3-C8 cycloalkyl group, a C3-C8 cycloalkyl-C1-C6 alkyl group, an aryl group, an aryl-C1-C6 alkyl group, a heteroaryl group, or a heteroaryl-C1-C6 alkyl group; R and R' are independently H, a linear or branched C1-C6 alkyl group, a C3-C8 cycloalkyl group, an aryl group, or an aryl-C1-C6 alkyl group, or can form a ring together; and R'' is a linear or branched C1-C6 alkyl group, a C3-C8 cycloalkyl group, an aryl group, or an aryl-C1-C6 alkyl group.
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