USO DELLA FRACTALCHINA PER LA PRODUZIONE DI UN FARMACO NEUROPROTETTORE CONTRO LA MORTE CELLULARE

摘要

The present invention relates to the use of an endogenous protein of immunitary origin, fractalkine, as a neuroprotective agent against glutamate toxicity in case of acute cerebral ischemia and spinal cord lesions. The agent is useful also in neurosurgery during operations on the brain as neuroprotective agent in case of blockage of blood circulation in the localized brain region subject to surgical intervention. Neuroprotection is exerted in the interval of a few hours after the ischemic insult and thus should be considered unique in the described pathophysiological applications.