| 摘要 |
<p>New ligands for the ORL-1 receptor are described, useful for antagonising the activity of said receptors in a patient in need thereof, and for preventing and treating illnesses dependent on the activation of this receptor. The new compounds conform to structural formula (I). In formula (I) inter alia, at least one of the two R<SUB>4</SUB> substituents is a fluorine atom and at least one among R2 and R3 is a group -(CH<SUB>2</SUB>)<SUB>n</SUB>-CONR<SUB>a</SUB>R<SUB>b</SUB>, where R1, R2, R3, R4, n, R<SUB>a</SUB>, R<SUB>b</SUB> are defined in the description.</p> |
