| 摘要 |
<p>The invention relates to a microf luidic device for promoting crystallisa tion of target molecules, such as proteins. The device comprises a solid str ucture with a top face and an opposite bottom face and with a least one liqu id channel. The liquid channel comprises a target molecule solution inlet (2 4) and at least two precipitant inlets (26). The target molecule solution in let is in liquid communication with each of the precipitant inlets through t he liquid channel. The liquid channel comprises a branching channel section (27) adjacent to the target molecule solution inlet, crystallisation channel sections (29) adjacent to the respective precipitant inlets and flow break channel sections (28) arranged between the branching channel section (27) an d each of the crystallization channel sections (29). The liquid channel is b ranched from 1 to X in the branching channel section (27), wherein X is the number of crystallisation channel sections, and the flow break channel secti ons (28) comprise a flow break arrangement (28a) capable of breaking up the liquid communication between said respective branching channel section and c rystallisation channel sections.</p> |
