| 发明名称 |
Antibodies against tumor surface antigens |
| 摘要 |
The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity antibodies against carcinoembryonic antigen (CEA), especially the antibody we have termed sm3E, which is derived from the scFv antibody MFE-23. Such antibodies have the potential for improved therapeutic efficacy.
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| 申请公布号 |
US2008003646(A1) |
申请公布日期 |
2008.01.03 |
| 申请号 |
US20070802989 |
申请日期 |
2007.05.29 |
| 申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
BEGENT RICHARD J.;CHESTER KERRY A.;GRAFF CHRISTILYN P.;WITTRUP K. D. |
| 分类号 |
C12P21/02;C07K16/00;C07K16/30;C12N1/19;C12N15/13;C12N15/81 |
主分类号 |
C12P21/02 |
| 代理机构 |
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代理人 |
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| 主权项 |
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