METHODS FOR IDENTIFYING MODULATORS OF EOXIN FORMATION

摘要

A method for identifying a compound for modulating the formation of 14,15-LTC<SUB>4 </SUB> (Eoxin C<SUB>4</SUB>; EoxC<SUB>4</SUB>), 14,15-LTD<SUB>4</SUB> (Eoxin D<SUB>4</SUB>; EoxD<SUB>4</SUB>), or 14,15-LTE<SUB>4</SUB> (Eoxin E<SUB>4</SUB>; EoxE<SUB>4</SUB>) in a biological system. A method for identifying a compound with an anti-inflammatory effect, the method comprising testing the compound for an effect on formation and/or activity of 14,15-LTC<SUB>4</SUB> (Eoxin C<SUB>4</SUB>; EoxC<SUB>4</SUB>), 14,15-LTD<SUB>4</SUB> (Eoxin D<SUB>4</SUB>; EoxD<SUB>4</SUB>), or 14,15-LTE<SUB>4</SUB> (Eoxin E<SUB>4</SUB>; EoxE<SUB>4</SUB>) in a biological system. A method of making an anti-inflammatory composition or Eoxin formation-modulating composition comprising (i) identifying an anti-inflammatory compound or Eoxin formation-modulating compound by a method of the invention; (ii) combining the compound with a pharmaceutically acceptable excipient or carrier.