发明名称 |
Method of Obtaining Idolocarbazoles Using Biosynthetic Rebeccamycin Genes |
摘要 |
Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.
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申请公布号 |
US2008004326(A1) |
申请公布日期 |
2008.01.03 |
申请号 |
US20020493000 |
申请日期 |
2002.10.17 |
申请人 |
SANCHEZ REILLO CESAR;FERNANDEZ BRANA ALFREDO;SALAS FERNANDEZ JOSE ANTONIO;MENDEZ FERNANDEZ CARMEN |
发明人 |
SANCHEZ REILLO CESAR;FERNANDEZ BRANA ALFREDO;SALAS FERNANDEZ JOSE ANTONIO;MENDEZ FERNANDEZ CARMEN |
分类号 |
A61K31/403;A61P35/00;C07D307/93;C07H19/04;C07H21/00;C07K14/00;C12N1/00;C12N1/20;C12N1/21;C12N15/11;C12N15/52;C12N15/63;C12N15/76;C12P17/18;C12P19/28 |
主分类号 |
A61K31/403 |
代理机构 |
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主权项 |
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地址 |
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