Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents

摘要

This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R¹ and R² are independently of each other hydrogen atom, C_1-6alkyl group or C_6-14aryl group, R³ is hydrogen atom or C_1-6alkylcarbonyloxy group, or together with R⁴ forms a bond, R⁴ is hydrogen atom, or together with R³ forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR⁷R⁸, NR⁹, O, S, SO or SO₂, R⁵ is hydrogen atom or C_1-6alkyl group, R⁶ is hydrogen atom, C_1-6alkyl group, C_3-8cycloalkyl group, C_3-8cycloalkenyl group, amino group, C_1-6alkylamino group, di-C_1-6alkylamino group, C_6-14arylamino group, C_2-9heteroarylamino group, C_6-14aryl group, C_2-9heteroaryl group or C_2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.