PSEUDO PROLINE DIPEPTIDES

摘要

Disclosed is a three step process for the manufacture of pseudo proline dipeptides of the formula (I) wherein R¹ is a side chain of an alpha amino acid , R² is an amino protecting group and R³ and R⁴ are independently selected from hydrogen or C_1-4-alkyl, R⁵ is hydrogen or methyl starting from an amino acid derivative of the formula (II) wherein R¹ and R² are as above. Pseudo proline dipeptides can be used as reversible protecting groups for Ser, Thr and Cys and thus are versatile tools in peptide chemistry.