发明名称 |
METHODS FOR TREATING AND PREVENTING FIBROSIS DUE TO SCHISTOSOMIASIS BY IL-21 / IL-21R ANTAGONISTS |
摘要 |
<p>The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21 R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21 R gene products), and/or the level of interaction of IL-21 with IL-21R).</p> |
申请公布号 |
EP1871800(A1) |
申请公布日期 |
2008.01.02 |
申请号 |
EP20060750009 |
申请日期 |
2006.04.13 |
申请人 |
WYETH;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
YOUNG, DEBORAH, A.;WYNN, THOMAS, A.;COLLINS, MARY;GRUSBY, MICHAEL |
分类号 |
C07K14/715;A61K38/17;A61K39/395;A61P17/02;C07K16/24;C07K16/28 |
主分类号 |
C07K14/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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