ATTENUATED CHIMERIC FLAVIVIRUS BEARING ATTENUATED JAPANESE ENCEPHALITIS VIRUS GENE AS BACKBONE
摘要
<p>A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.</p>
申请公布号
EP1840214(A8)
申请公布日期
2008.01.02
申请号
EP20050822652
申请日期
2005.12.22
申请人
THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OFOSAKA UNIVERSITY