发明名称 |
CALCIUM BIS[2S)-3-[3-(2S)-3-(4-CHLORO-2-CYANOPHENOXY)-2- FLUOROPROPOXY¨PHENYL]-2-ISOPROPOXYPROPIONATE] AND INTERMEDIATE THEREOF |
摘要 |
<p>The present invention relates to calcium bis[(2 S )-3-[3-[(2 S )-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate] represented by formula (I), a hydrate thereof, a crystal of the compound of formula (I), and a crystal of the hydrate of the compound of formula (I) which are useful as pharmaceuticals, and to processes for producing the same, and intermediates therefore, and processes for production thereof. [Problem] There is need for (2 S )-3-[3-[(2 S )-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, in the form of a drug substance, purified so as to minimize a residual solvent content and having a uniformized specification and a highly favorable workability, and a process for producing the same. [Solution] Crystalline calcium bis[(2 S )-3-[3-[(2 S )-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate], a calcium salt of (2 S )-3-[3-[(2 S )-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, solves the above problem.</p> |
申请公布号 |
EP1873141(A1) |
申请公布日期 |
2008.01.02 |
申请号 |
EP20060745431 |
申请日期 |
2006.04.18 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
SHINODA, MASANOBU;MATSUURA, FUMIYOSHI;MURATA, KAORU;GOTODA, MASAHARU;HAYASHI, KENJI;SASHO, MANABU;OZEKI, NOAKI;INOUE, SUSUMU;NISHIURA, KATSUTOSHI;HISATAKE, YOSHIHIKO;TAKIGAWA, TEIJI;MIYAZAWA, MAMORU;NEGI, SHIGETO;MATSUYAMA, KEISUKE |
分类号 |
C07C255/54;A61K31/277;A61P3/04;A61P3/06;A61P3/10;A61P19/10;A61P29/00;C07C51/353;C07C59/64;C07C253/30 |
主分类号 |
C07C255/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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