发明名称 |
Process for the cyanation aldehydes |
摘要 |
A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si-CN bond or a C-(C-O)-CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.
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申请公布号 |
US7314844(B2) |
申请公布日期 |
2008.01.01 |
申请号 |
US20050114068 |
申请日期 |
2005.04.26 |
申请人 |
KING'S COLLEGE LONDON;NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS |
发明人 |
NORTH MICHAEL;BELOKON YURI |
分类号 |
B01J31/36;B01J31/18;B01J31/22;C07B53/00;C07C253/00;C07C255/14;C07C255/15;C07C255/38 |
主分类号 |
B01J31/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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